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ntroduction:Urinary tract infections (UTI) are a leading cause of bacterial infections in humans.The widespread use of antibiotics has resulted in the emergence of antibiotic-resistant microorganisms. Hence the current study was conducted to investigate the antibiotic sensitivity pattern of uropathogens in urinary tract infection.
Materials and Methods:A total of 642 urine samples were collected from suspected UTI patients and tested microbiologically as well as antimicrobial susceptibility tests were performed for the isolated pathogens using Kirby- Bauer disk diffusion method.
Results:Out of 642 urine samples 308(48%) samples were found to contained significant bacteriuria. Females have a higher rate of UTI (68%) than males (32%). The most common organism was E. coli (57.2%), followed by Klebsiella (26.3%). UTI was more common in patients of middle-age group (31 to 45 years). Among females while in males high prevalence was seen among old age (>45 years) group patients 60-70years.Meropenem, Gentamicin, Nitrofurantoin, Co-Trimoxazole, and Tetracycline were the most sensitive drugs against E. coli and Klebsiella, but they were more resistant to Amoxycillin, fluoroquinolones, and ceftriaxone.
Conclusion:Because of the uncontrolled use of antibiotics, commonly isolated uropathogens have a changing resistance pattern, resulting in reduced the effectiveness and safety of the treatment; therefore, sensitivity and resistance pattern of uropathogens to common antimicrobial agents must be taken into account when selecting treatment plans for UTI.