“In vitro evaluation for the anti-fungal activity of Homoeopathic Medicine Sepia against Trichophyton rubrum infection”

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Dr. Katravatu. Nanaku Naik, Dr. Chetan H Shinde, Dr. Bipinraj NK


Background: The prevalence of dermatophytes infections or Tinea or Ringworm is worldwide. Due to the resistance to conventional therapy and the high chance of recurrence of these infections, there is a need to develop an alternative therapy like Homoeopathy. Homoeopathic medicines are broadly used for various fungal infections with gentle and permanent results; however, their preclinical assessment remains a key challenge.

Objectives: This study aimed to screen the antifungal activity of Sepia against T. rubrum in-vitro.

Hypothesis: We hypothesize that all potencies of homoeopathic medicine Sepia can inhibit the growth of T. rubrum.

Methods: Homoeopathic medicine Sepia in different potencies (6C, 12C, 30C, 200C, 1M) were evaluated for antifungal activity against T. rubrum (MTCC-296) using the agar well diffusion method. The diameter of the zone of inhibition (mm) was measured and potency of Sepia having high MIC was determined and results were compared with positive control Clotrimazole.

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