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Chronic kidney disease (CKD) associated with abnormalities of mineral bone metabolism. These changes start in early stages and they get worse with disease progression. The purpose of our study is to correlate renal echogenicity with serum creatinine, eGFR, vitamin D, RBC and Urea in in order to determine the significance of renal echogenicity when it comes to identifying the progression of chronic kidney disease (CKD). Study includes the normal and CKD patient’s total of 52individuals (23 males; 29 female). Venous blood samples were collected from all the patients and control subjects. There was significant rise in serum creatinine levels with progression of disease means from G3 to G5 stages.Based on this result it can be said that changes in the serum levels, serum creatinine were significant in relation to progression of disease. This underlines the importance of early diagnosis of mineral bone abnormalities, need of understanding the pathophysiology and planning management to prevent the progression.