Laser Management of Potentially Malignant Disorders: A Systematic Review with Meta-Analysis

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Fahdah Aldahash, Roshan Mahmoud Abuzaid, Yara Abdullah Alkinani, Reema Fahad Alsnaidi


Background:Oral cavity cancer accounts for about 3% of all malignancies identified each year in thousands of people over the world. Many oral squamous cell carcinomas arise from potentially cancerous conditions (PMDs).The aim of this systematic review is to analyse the role of laser therapy in the treatment/management of oral PMDs.

Methods: Using the PRISMA framework, a thorough review of research published between 2012 and 2019 that were listed in the PubMed, Web of Science, and Cochrane library databases was performed which revealed 592 papers, 168 of which were thoroughly evaluated. Exclusion and inclusion criteria were used to choose studies that were applicable for our review.

Results: Significant improvements were observed after the application of laser therapy in the condition of the patients suffering from PMDs in the studies that were selected for this systematic review.

Conclusion: In this review, majority of PMD patients were disease-free following laser excision of dysplastic mucosal lesions, and the risk of malignant transformation remained relatively low. This is a clear indicator of the fact that the management of PMDs with laser therapy is a reliable technique associated with minimal complications, discomfort and suitable for routine clinical practice.

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