Synthesis of Manganese Nanoparticles of Oolong Tea Extract by Sonication Method for a Natural Oral Contrast Media on Magnetic Resonance Cholangiopancreatography (MRCP)

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Fatimah Fatimah, Neni Susilaningsih, Hermina Sukmaningtyas, Agus Subagio

Abstract

Magnetic resonance cholangiopancreatogrphy examination using natural contrast media has not been able to provide an optimal image of gastroduedenal suppression that covers the image of the biliary system. Natural materials used as contrast media continue to be developed with various previous studies, but not many have been associated with the use of nanoparticles as natural contrast media materials. This study aims to make manganese nanoparticles in oolong tea extract used as an oral contrast medium. In this experimental study, the extraction of oolong tea using the boiling method with 15 ml of distilled water was dissolved in 200 ml of distilled water and then sonicated with a frequency of 20 kHz with time variations of 10, 15, 20 and 25 minutes. The results of the sonication process carried out a Particle Size Analyzer (PSA) test. Furthermore, the obtained manganese nanoparticles were given orally to healthy volunteers and an MRCP examination was performed. In the resulting MRCP image, the SNR value is measured in the stomach, duodenum and biliary tract system. Synthesis of manganese nanoparticles with the sonication method showed that sonication for 10 minutes resulted in manganese particle sizes with a diameter of 1364.8 nm, 15 minutes with a diameter of 1204.7 nm, 20 minutes with a diameter of 488.2 nm, 25 minutes with a diameter of 1131.8 nm. The results with the particle size with a diameter of 488.2 nm are nanoparticles, then used for MRCP examination. manganese nanoparticles from oolong tea extract can suppress objects that cover the pancreatic biliary tree system, while increasing contrast enhancement in the pancreato biliary tree system.

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