Hepatoprotective Activity of Silymarin against paracetamol- Induced Liver Injury: A Review

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Noor Ahmed Abed, Musab Mohammed Khalaf, Mohammed Khalid Jamaludeen Alnori


The liver is a vital organ with central role in metabolism of different substances. Hepatic ailmentscanbe caused by diverse chemicals, such as high doses of some drugs or toxic compounds. Paracetamol is safe at the therapeutic doseand used as antipyretic and analgesic agent but with anoverdose may result in severe hepatotoxicity. N-acetyl-p-benzoquinone imine (NAPQI) is a paracetamol metabolite that is highly reactivewhich has the responsibilityofparacetamol toxicity. Silymarin is a mixture of flavonolignan isomers which are extracted from seeds of milk thistle plant. Silibinin is the main component of silymarin. Both of them are used for hepatoprotection. Silymarin  has numerous clinical applications to treat liver diseases from different origins. As a hepatoprotective drug, silymarin has been reported to possess a cell regenerating effect, antioxidant activity as free radical scavenger and lipid peroxidation inhibitor, increasing glutathione level and antioxidant enzymes, controlling cell membrane permeability prevents entry of hepatotoxins, furthermore, silymarin has antifibrotic, antiviral, anti-  inflammatory and immunomodultory activities. So the main objective of this review is highlight on this hepatoprotective effect of Silymarin.

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