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The simulations reveal that women entrepreneurs have been hardest hit by the COVID-19 pandemic. Factories, shops, and many other businesses were closed by the Government order. Many of these business closures are permanent. Small businesses around the world have been hit hard by the spread of the COVID-19. This research is therefore being conducted to assess the impact of COVID-19 on women-owned firms. Convenience sampling technique was used for primary data collection. Sample size was 100 women entrepreneurs in Northern Tamil Nadu. Data analysis was done through path analysis. The research discovered that there is impact of factors of COVID-19 pandemic such as social distance and worker absenteeism on challenges on women entrepreneurs. It is found that there is impact of challenges faced during COVID-19 pandemic on intention to quit among women entrepreneurs. The research also discovered that there is impact of factors of COVID-19 pandemic such as social distance and worker absenteeism on intention to quit among women entrepreneurs. Hence, it is concluded that the policymakers need to develop a comprehensive national policy for women entrepreneurs. Through good national policy, women entrepreneurs can stem from the effects of the COVID-19 pandemic.