The Therapeutic Effect of Gum Arabic on Nephrotoxicity that Induced by Anticancer Drug Carboplatin in Male Rats

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Marwa A. Alshorbage, Banan R. Dabdoub

Abstract

This research was conducted to reduce the side effects resulting from cancer drugs to reduce the encumbrance on cancer patients, as chemotherapy causes harmful side effects despite its usefulness in treatment. In addition, gum Arabic is used in alternative medicine to reduce kidneydamage.


In this study, 24 adult male rats were separated into four groups, with the first group (6n) receiving a normal saline injection intraperitoneally, and the second group (6n) injected intraperitoneally with normal saline after 48 hours; they were given gum Arabic (15%) with drinking water for a period 30 days. the third group was injected intraperitoneally with carboplatin(50mg/kg) single dose, and the fourth group was injected single dose of carboplatin(50mg/kg) and after 48 hours was given gum Arabic (15%) with drinking water for 30 days.After the period, animals were sacrificed, blood and kidneys were collected for tests. When compared to the control group, the third group injected with carboplatin exhibited a reduction in white blood cells, red blood cells, platelets, Hemoglobin concentration, the packed volume of cell blood, and erythropoietin. There is a rise in the proportion of blood urea, uric acid, and creatinine when compared to the control group.


As for the fourth group, noticed an increase in the percentage of hematological parameters and erythropoietin and its proximity to the control group and a decrease in the percentage of EPO, Blood urea, Uric acid, and creatinine.

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