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Ki-67 is a cell proliferation marker that is utilised as a diagnostic tool in the pathologic differentiation of a variety of lesions. It's also important for designing molecular medicines that are specific to a patient's needs. The Ki-67 labelling index (LI) in odontogenic cysts and tumours was evaluated in a comprehensive study. PubMed (MEDLINE), Scopus, CINHAL, PsycoInfo, the Cochrane Library, and Proquest were among the databases examined. A meta-analysis was conducted using data from 608 lesions. When a 5% cut-off criterion was established, the ki-67 LI of all benign odontogenic tumours fell below it. All of the malignant tumours had a LI of > 15.3%, with malignant odontogenic lesions having a substantially higher Ki-67 LI (17.59 2.80). Ameloblastoma (4.39 0.47) and adenomatoid odontogenic tumour (0.91 1.71) had the biggest and lowest Ki-67 LIs among benign tumours, respectively. Ki-67 LI had mean levels of 4.23 and 1.04 in tumours and cysts, respectively. The odontogenic keratocyst (OKC) had the greatest Ki-67 LI (3.58 0.51 percent), whereas the radicular cyst had the lowest (1.29 0.62 percent). Except for OKC, Ki-67 LIs in all odontogenic cysts were less than 3%. This contentious lesion seems to have a profile more like to that of a tumour, suggesting that a treatment regimen similar to that of malignancies be considered. We discovered that odontogenic lesions exhibit a wide range of proliferative activities that assist distinguish between distinct lesions and provide treatment options.