Understanding Microbial and Genetic Aspects of Amyotrophic Lateral Sclerosis

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Garima Rastogi, Varun Sharma, Ekta Rai, Vinod Singh, Swarkar Sharma

Abstract

Amyotrophic Lateral Sclerosis (ALS) is a clinically progressive neurological disorder characterized by degeneration of neurons ultimatelyaffecting the ability of the brain to control voluntary muscular movement. The early diagnosis of this disease is critical because (i) initial symptoms vary among different ethnic groups around the world and (ii) differentiatingthe other disorders which mimics symptoms as ALS. Further, with recent reports of microbial involvement in the disease etiology, the overall perspective of the development of the disease becomes complicated. This complex nature of ALS necessitates the proper understanding of the disease so that appropriate healthcare strategies could be developed.This review is an attempt to have an overview of the current scenario of ALS.It also discusses the importance of diagnosis, treatment, understanding of the etiology of ALS and potential roleof the micro-organismsin disease, for better understanding.

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