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Chronic hepatitis B (CHB) is a global epidemic that can cause fibrosis, cirrhosis, and hepatocellular carcinoma. Galectins have the ability to regulate both intracellular and extracellular cell death. In this study, we attempted to see if there is any relationship between Gal-9 with ALT, AST, ALP, T. BIL, D. BIL, IN.BIL, TSP, Albumin, and Globulin. This research included 40 patients from Fallujah city, whoever was having CHB disease, with 40 there were also healthy controls registered. Serum ALT, AST, T. BIL, D. BIL, IN. BIL, ALP, TSP, Albumin, and Globulin Colorimetric methods were used to estimate concentrations. Gal-9 concentrations were estimated by, enzyme linked immunosorbent assay (ELISA) technique. Levels of in serum Gal-9, ALT, AST, ALP, T. BIL, D. BIL, IN. BIL and Albumin were higher in CHB patients ( P< 0.0001) in comparison with healthy controls, but TSP , Globulin concentrations were lower in CHB patients in comparison to controls (P= 0.6843) and (P < 0.0001) respectively, serum Gal-9 concentrations related positively with serum ALT, AST, ALP, T. BIL, D. BIL, IN. BIL , Albumin and negatively correlated with Globulin concentrations (all P<0.01), the area under the receiver operating characteristic (AUROC) curve of ALT and AST[AUROC=1], T.BIL, Albumin , D.BIL , IN.BIL, globulins, ALP ,levels were, 0.9588 , 0.9222 , 0.9197, 0.9084, 0.8559, 0.7678 respectively, in conclusion serum levels of Gal-9 can use as in diagnosis CHB disease, also it may be use in manufacture treatment of CHB disease.