Detection of Helicobacter Pylori Antigen in Stool Samples of Patients with Upper Gastrointestinal Symptoms

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Shahad Nazar Mustafa, Morooj Ali Fahad, Entisar Mahdi Hamad, Nabaa Ali Jasim, Fatima Malallah Mohammed


Background: Helicobacter Pylori bacterium colonizes more than half of the human world’s population, particularly in developing countries, and is well known to cause some upper and lower gastrointestinal problems and may cause stomach cancer, which can be identified in various diagnostic ways, including stool antigen testing technique.

Objective: Detect the Helicobacter Pylori antigen in stool samples for cases with upper gastrointestinal symptoms and determine the prevalence of infection with regard to age and sex, the most common symptoms and family history of gastrointestinal disturbances.

Materials and methods: The study designed as an observational, descriptive using convenience sampling. Stool samples were collected directly from all cases complaining of symptoms associated with the upper gastrointestinal tract after obtaining initial approval to participation, where the study included 124 cases (42 males, 82 females), carried out on all adults aged 18-71 years during the period from March 18 to November 30, 2021.HpSA stool antigen test was used to detect Helicobacter Pylori. After collecting all the data, the SPPS was used to perform the statistical analysis of the results. Both the Chi-square test and the Binomial test were used to assess the difference between the study variables. 95% confidence intervals and a P value of less than 0.05 were taken into account.

Results: The results of the study showed that positive cases of the Helicobacter Pylori stool antigen (HpSA) (71.8%), had the highest percentage of positive cases (43.8%) significantly in the younger age groups (18-30) years, especially among females (67.4%). Most positive patients (67.4%) suffered significantly from stomach pain accompanied by vomiting and nausea.

Conclusion:The prevalence of Helicobacter pylori infection was found to be significantly high, especially among younger ages, female sex, patients with stomach pain accompanied by vomiting and nausea.

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