Study of Antibiotic Sensitivity Pattern in Urinary Tract Infection

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Noor alhooda. M. Al awkally, Hamza Khalifa Ibrahim, Maree Dokally Ali, Fares M Muthanna, Alreda Miloud Al-Awkally, Aejeeliyah Yousuf

Abstract

Urinary tract infection (UTI) is one of the principal causes of infection worldwide. This study aimed to determine the etiological bacterial pathogens of the UTI and to determine the antibiotic sensitivity pattern of pathogens isolated. Urine samples were tested in the microbiology department of Tobruk Medical Center, Tobruk, Libya from January 2021 to December 2021. The resulted diameters of inhibition zones around the antibiotic discs were measured to the nearest whole mm and interpreted according to protocols standardized for the assay of antibiotic compounds as guided by the National Committee for Clinical Laboratory Standards.Out of 1372 patients, isolates were detected in 171 (12.4%) specimens. Out of these, 137 (77.40%) were female and 40 (22.60%) were male. The prevalence of uropathogens isolated from patients was E. coli, followed by Klebsiellaspp and Proteus spp. In the In Vitro Antibiotic Sensitivity Pattern of Uropathogens, it was seen that E. coli and Klebsiellaspp were highly sensitive to Gentamycin, Nitrofurantoin, and Septrin. At the same time, E. coli and Klebsiellaspp were highly resistant to chloramphenicol and augmentin. The most effective antimicrobial agent against most bacteria was Gentamycin, followed by Nitrofurantoin. The study found a significant difference between isolated bacteria and gender (p= 0.002). Klebseilla spp. were isolated in abundance in July and December 2021, respectively. The highest isolation of E. coli was in October and November equally. In view of this study's findings, we recommend Gentamicin, Nitrofurantoin, and Septrin as drugs of choice in treating urinary tract infections based on their high sensitivity.

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