Prevalence of Helicobacter Pylori Induced Gastritis with Histopathologic Correlation in a Tertiary Care Hospital

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Vinutha Gali, Sai Sudha M., Yengkhom Daniel Singh, Mary Lilly

Abstract

Background:Helicobacter pylori associated upper gastrointestinal disorders ranges gastritis, peptic ulcer and gastric malignancies. H pylori elicits an acute inflammatory response that is either asymptomatic or symptomatic with intermittent manifestations like epigastric pain, nausea and vomiting, which eventually evolves into a long-standing infection, chronic gastritis.


Materials and methods: A descriptive study was conducted on a total of 129 non-neoplastic gastric biopsy specimens sent by the Gastroenterology department in our hospital from a time period of one year. Specimens were stained with hematoxylin & eosin and Giemsa stain for the histopathological section of all specimens.


Results: Out of the total number of 129 cases, overall prevalence of Helicobacter pylori was found to be 28(21.7%). Prevalence in males (64.3%) was higher as compared to females (35.7%). There was association of histomorphological changes like erosion in 5(17.9%), ulceration in 3(10.7%) and intestinal metaplasia in 3(10.7%) with Helicobacter pylori infection.


Conclusion: Helicobacter pylori is uncommon among the patients who underwent gastric biopsies in our hospital. Middle aged male patients had a preponderance of the infection. A wider and longer study period with population-based data may be required to assess the true burden of the disease.

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