Impacts of CD14-159 and IL4 Gene Polymorphisms on Course Intensity of COVID/19 A Cross-Sectional Study among Iraqi Population

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Manal M. Kadhim, Dhuha A. Hassan

Abstract

Background and Objective:Despite of the COVID-19 pathogenesis and severity of the infection still completely unclear, but the human’sgenetic variation in gene participate in SARS-COV2 infectivity, inflammation and immunity response might have a great association with severity of clinical out-comesof nCoV-2019 disease. This study evaluates the impact of CD14-159 and IL4 genotypes on the severity of SARS-COV2 infection.


Materials and method: Thisresearchhave been done with one hundred individuals from Al-Qadisiyah governorate in Iraq, whom infected with SARA-COV2. The patients have been divided into three subgroups according to severity of clinical symptoms; mild, moderate and severe groups.RFLP-PCR technique has beenworked out to specify genes polymorphisms.


Results: Statistically, significant association have been observed between CD14-159 CT gene polymorphisms and severity of the disease, with higher frequency of CD14-159CC homozygote among patients with severe course of disease (P =0.011, OR: 3.37, 95% CI= 1.29-8.78, etiological fraction EF of 0.31). There are no significant differences in IL4 genotypes among the patients’ subgroup, but in respect to the allele, the difference is significant.


Conclusions: The study has shown that in addition to age, gender and clinical history of the patients, the genetic variation of CD14-159C/T genotype has an association with prognosis and severity of SARS-Cov2 infection, while IL4 SNP has no impact on clinical course of ‘COVID/19’.

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