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Phytochemicals found in plant extracts have previously been shown to have anticancer and chemo preventive properties. Although Vanda spathulata is a rich source of phytocompounds, nothing is known about its anticancer properties. The goal of this research was to see whether V. spathulata leaf extracts had anticancer properties by looking at how they affected MCF-7 cell growth and apoptosis. (Human Breast Adenocarcinoma). Leaves were extracted using the solvent Methanol. MTT was used to investigate anticancer activity (3- (4,5-dimethylthiazol-2yl) -5- (3-carboxymethoxyphenyl) -2- (4-sulfophenyl) -2H-tetrazolium) assay on breast cancer cells MCF-7. Five strengths of methanolic leaf extract (12.5, 25, 50, 100, and 200 g/mL) were tested for their cytotoxicity. When methanolic leaf extract concentrations were increased, cell viability decreased significantly, and cytotoxicity increased, as assessed by MTT. In MCF 7, the IC50 values of methanolic leaf extract of V. spathulata extract were 113.07g/mL.