The Difference of S100B Levels in Inhalation Anesthesia and Intravenous Totals against the Incidence of Cognitive Dysfunction after Elective Orthopedic Surgery

Main Article Content

Jody Satrio Prabowo, Christrijogo Soemartono W., Herdiani Sulistyo P.

Abstract

This study aims to analyze differences in blood levels of pre and postoperative S100B in patients undergoing elective orthopedic surgery with inhalation and intravenous anesthesia, as well as to analyze the relationship of differences in blood levels of pre and postoperative S100B to the incidence of POCD. This study was a paired categorical comparative analytical study with a cross sectional design to analyze differences in blood levels of S100B in patients undergoing elective orthopedic surgery with inhalation and intravenous anesthesia. This research take a place at GBPT of Dr.Soetomo Hospital during the period March – April 2022. The target population is patients undergoing elective orthopedic surgery at GBPT of Dr.Soetomo Hospital. The results indicates that the incidence of Postoperative Cognitive Dysfunction (POCD) in the inhalation anesthetic group was 4 (19%). There was no incidence of POCD in the intravenous anesthesia group (TIVA) in the study subjects. There are differences in the pre- and postoperative blood levels of S100B in inhalational anesthetic patients. There are differences in pre- and postoperative blood levels of S100B in patients with intravenous anesthetic agents. There is a relationship between pre- and postoperative levels of delta S100B on the incidence of POCD in research subjects.

Article Details

Section
Articles