Pathological Alterations Induced by Salmonellatyphimiurm in the Mice Treated with Olive Leaves Alcoholic Extract and Ciprofloxacin

Abstract

     This study  was designed in order to study the pathological alterations cause by Salmonella typhimiurm in the mice that treated with Olive Leaves Alcoholic Extract and Ciprofloxacin .In experimental we use One-hundred mice both gander were divided randomly: 1^stgroup was infected with 0.2ml /4×10⁸ CFU/ ml I/V of  S. typhimiurm. 2^nd group were infected  I/V with S. typhimiurm0.2 ml 4×10⁸ CFU/ ml and injected 30mg/kg /0.4ml of Ciprofloxacin I/M,3^rdgroup was given  as pre-treated Olive leaf alcoholic extract 2 weeks after that  injected with I/V 0.2 ml /4×10⁸ CFU/ml S. typhimiurmthen  post-treated with 30mg/kg /0.4ml of Olive leaf alcoholic extract orally until the end of experimental (60days). 4^th group that were given 30mg/kg /0.4ml of Olive leaf alcoholic extract orally only. Results showed sever deposition of apoptosis marker in several organs and heavy devastating and necrotic altrationwith sever inflammatory reaction. Conclusion, experimental detect that Salmonella typhimiurm be highly virulence bacterial pathogen to induced apoptosis and necrosis in infective organs and  tissues.