Features of the Clinical Course, Diagnosis and Treatment of Resistant Forms of Pulmonary Tuberculosis

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Usmonov I. Kh., Jumaev M. F.

Abstract

A survey of 244 patients from the southern regions of the Republic of Uzbekistan was carried out in the period from 2016 to 2020. The age of patients ranged from 18 to 86 years, the average age was 52.1±2.9 years, men were 2.2 times more than women. It should be noted that the most common incidence occurred after forty years - 75.4% of patients and the peak age period was from 50 to 59 years in 23.4% of cases. Sick rural population was observed - in 185 (75.8%), urban population - in 56 (23.0%) and homeless people - in 3 (1.2%) cases. The analysis noted that the disease was 3.3 times more common in rural populations. The duration of complaints of patients before establishing the final diagnosis ranged from 1 month to 10 years, on average 6.3±1.7 months.


Bacterioscopy examination revealed MBT in 154 (63.1%) cases, and 90 (36.9%) cases of MBT were not detected. Sowing of pathological material was carried out on the solid medium of Levenshtein-Jensen - in 229 (93.9%) patients and in 206 (89.9%) cases, growth of colonies of Mycobacterium tuberculosis was noted. And the liquid medium BACTEC MGite 960 - in 15 (6.1%) cases and 11 (73.3%) cases, a positive result was obtained. PCR diagnostics was carried out in the Gene / Xpert device - in 244 (100%) patients and 237 (97.1%) cases, DNA of mycobacterium tuberculosis was detected, and in the HAINtest ​​device - in 164 (67.2%) cases and 100% of cases positive result.


Of the 244 cases, 242 (99.2%) patients are alive, 2 (0.8%) cases have been observed death due to complications and concomitant diseases, 34.8% of cases have relapses.

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