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Background: Periodontitis is an inflammatory condition that results in pocket formation, gingival recession, and tooth loss by gradually destroying the periodontium. An alternate therapeutic approach that can address all of these problems is required due to the prohibitive cost of periodontal therapy, unfavourable antibiotic side effects, the advent of novel bacterial strains, and the resistance of those strains. The major goal of our study was to assess Nigella sativa L.'s antibacterial effectiveness against P. gingivalis utilising seed extract. Methodology: Six individuals with periodontitis, both male and female, between the ages of 30 and 50, were enrolled in the study. Each patient's medical and dental histories were documented. Then, in the microbiology lab, anaerobic procedures were carried out to find P. gingivalis development. The specimens were all then cultured.
Results: Although N. sativa samples had somewhat less antibacterial activity than tetracycline samples, it was discovered that N. sativa had noticeably strong antibacterial activity against P. gingivalis.
Conclusion: Our findings suggest that N. sativa can be utilised against periodontitis as an adjunct to scaling since it has high antibacterial action against Porphyromonas gingivalis.