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This study is designed to investigate the effect of acarbose and olive leaf extract (OLEU)on some metabolic parameters in adult male rats exposed to high fructose and 0.5% hydrogen (H2O2) peroxide (HFr- H2O2).Thirty-two adult male rats were placed into four equal groups at random and received the following care for two months: Control (CC),received drinking water orally; T1, rats were received 40% fructose in drinking water and given orally 0.5% H2O2 (HFr- H2O2 group); T2, animal were handled as in group T1 in addition to given orally acarbose 30mg/kg, and T3 group, HFr- H2O2 exposed animals were given orally combination of acarbose as in T2 and olive leaf extract 50mg/kg.By using the heart puncture procedure, blood samples were obtainedat 0 day and after two months of the experiment for measuringthe serum concentration of the following parameters: lipid profile indices: Total cholesterol (TC), Triglycerides (TAG), Low density lipoprotein-cholesterol (LDL-c), High density lipoprotein-cholesterol (HDL-c) and very low-density lipoprotein -cholesterol (VLDL-c) concentrations and leptin hormone concentration. The results showed that exposure rat to 40% fructose in drinking water and 0.5% H2O2 (HFr- H2O2) orally for two months (T1 group) caused Significantly (p0.05) decrease in serum HDL-c concentration as compared to the value in the control and other treated groups, as well as an increase in the serum concentrations of TC, TAG, LDL-c, and VLDL-c. While oral intubation of acarbose or acarbose plus OLE to (HFr- H2O2) exposed rats in groups T2 or T3 caused restoration of lipid profiles as evidenced by significant (p0.05) increase in serum HDL-c and significant (p<0.05) decrease in serum TC, TAG, LDL-c, and VLDL-c concentrations compared to the value in T1 group, respectively. The result also showed significant increase (p<0.05) in serum leptin hormone concentration in T1 treated group comparing to the values in T2, T3 and control groups at the end of the experiment. Histopathological changes in liver were also observed in group T1 comparing to other groups. In conclusion, the results of this study pointed to the effect of acarbose as ant obesity in rats exposed to HFr- H2O2, besides the combination of OLEU with acarbose possessed additive effect.